Realnova Healthcare

FEATURES

• Contains Arteether, a semisynthetic derivative of artemisinin.

• Used for the treatment of severe and complicated malaria, especially Plasmodium falciparum resistant to other drugs.

• Administered intramuscularly for rapid action.

• Provides fast schizonticidal action on blood-stage parasites.

• Effective against chloroquine-resistant malaria strains.

• Helps in reducing fever and parasite clearance time.

• Usually given in short-course therapy (3-day regimen).

FEATURES OF B-ARTEETHER INJECTION:

• Active Ingredient: Alpha/Beta Arteether (commonly 150 mg per ml)

• Therapeutic Class: Antimalarial Injection

• Indication: Used for the treatment of severe and complicated malaria, especially caused by Plasmodium falciparum strains resistant to other antimalarials.

• Mode of Action: Rapidly acts on the blood schizont stage of the malaria parasite, leading to quick parasite clearance and symptom relief.

• Onset of Action: Fast-acting with effective reduction in fever and parasitemia.

• Dosage Form: Injectable oil-based solution for intramuscular administration.

• Treatment Duration: Short-course therapy, typically 3 consecutive days.

• Advantages:

  • High efficacy in resistant malaria cases

  • Rapid parasite clearance

  • Convenient once-daily dosing

  • Well-tolerated with minimal side effects when used as directed

• Storage: Store in a cool, dry place below 25°C. Protect from light.

• Packaging: Available in ampoules/vials suitable for hospital or clinical use.

FEATURES
Artesunate Injection IP

• Fast-acting antimalarial agent.

• Effective against severe and complicated malaria, especially Plasmodium falciparum.

• Water-soluble form ensuring rapid absorption and onset of action.

• Administered via intravenous (IV) or intramuscular (IM) route.

• Suitable for emergency management of severe malaria cases.

• Can be followed by oral antimalarial therapy for complete treatment.

• WHO-recommended drug for severe malaria treatment.

1. Rapid Action Against Malaria Parasites

   • Artesunate acts quickly on the Plasmodium parasite, especially P. falciparum, the most deadly species causing malaria.

2. Effective in Severe or Complicated Malaria

   • Recommended by the World Health Organization (WHO) as the first-line treatment for severe malaria.

   • Often used when oral therapy is not possible.

3. High Bioavailability

   • Injectable form ensures fast absorption and onset of action, vital in critical cases.

4. Well Tolerated

   • Generally well tolerated with fewer side effects compared to older antimalarials like quinine.

5. Parenteral Administration

   • Can be given via intravenous (IV) or intramuscular (IM) routes.

6. Conversion to Active Metabolite

   • Artesunate rapidly converts to dihydroartemisinin (DHA) — the active metabolite responsible for its potent antimalarial effect.

7. Short Half-Life, Rapid Parasite Clearance

   • Leads to quick reduction in parasite load and clinical symptoms such as fever.

8. Used in Combination Therapy

   • Often followed by a complete course of an oral ACT (Artemisinin-based Combination Therapy) to ensure total parasite clearance.